Dear Marko,
What would be wrong with separately realigning within session and between session images from Time 1 to MNI space, and then doing the same with Time 2 images. The resulting data should be all be optimally normalized to MNI, and it seems like direct comparisons from Time 1 and Time 2 could be achieved by statistical modeling (at least at the second level) by using Time 1 and Time 2 normalized beta images or contrast images.
Would be interested to hear why this might not be a viable approach.
Thanks,
Dan
Daniel H. Mathalon, Ph.D., M.D.
Professor of Psychiatry
University of California, San Francisco
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On Jun 27, 2014, at 8:20 AM, Marko Wilke <[log in to unmask]> wrote:
> Hi Patricia,
>
>> We feel it is not reasonable to enter all 8 runs in the same realign
>> with such a big distance. Or is it?
>
> You could try :) As mentioned by John in the past, between-session motion is handled differently from within-session motion, in that the algorithm will try to get all first (or mean) images from all sessions into one space in a first go. So it may actually work.
>
>> We tried to move the Time2 time series using the "reorient image" option
>> in checkreg, so they would be in rough alignment with the time series at
>> Time1 before the realign, but found out that as long as the images are
>> not resliced, the realign ignores those changes.
>
> It should not. Have you actually applied the changes to all images? Also, you could try "standard realignment" for all sessions from each session and then coregistration of the first/mean image of the first session from Time2 to the first/mean image of the first session from Time1, *taking along all images* from all sessions from Time2. You can also use the anatomical images if you have one from each timepoint, as they will provide better details and may be less vulnerable to different dropouts etc.
>
>> Is it ok to reslice the
>> images twice, once before and once after the realign? (we would like to
>> use dartel to register to the MNI space). Or is there a better solution
>> to our problem?
>
> Try the above. John has gone to great lengths to avoid instances where the data needs to be resliced; that alone tells us it is not a good idea :)
>
> Cheers,
> Marko
> --
> ____________________________________________________
> PD Dr. med. Marko Wilke
> Facharzt für Kinder- und Jugendmedizin
> Leiter, Experimentelle Pädiatrische Neurobildgebung
> Universitäts-Kinderklinik
> Abt. III (Neuropädiatrie)
>
> Marko Wilke, MD, PhD
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>
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