The disadvantage of lipase is that reagent carryover can cause problems. On the Abbott Architect many extra smart washes are required if lipase is on the test menu.
Mike Collins
Norfolk & Norwich NHS Trust
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Mohammad Al-Jubouri
Sent: 06 May 2014 16:03
To: [log in to unmask]
Subject: Re: Amylase vs Lipase
There is a limited number of head to head comparison studies of amylase and lipase diagnostic performance. This recent study suggests that lipase has better diagnostic performance over amylase but only marginally:
http://www.hkcem.com/html/publications/Journal/2011-1%20Jan/p020-025.pdf
regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP Edin, FRCPath
Consultant Chemical Pathologist
--------------------------------------------
On Tue, 6/5/14, Verrill Helen (RVW) Pathology <[log in to unmask]> wrote:
Subject: Re: Amylase vs Lipase
To: [log in to unmask]
Date: Tuesday, 6 May, 2014, 13:26
We often wonder that
we seem to be one of the few labs using pancreatic amylase,
however I suspect we'll be changing to lipase due to
change of analytical platform, Regards Helen Consultant Clinical
ScientistNorth Tees &
Hartlepool NHSfT
From: Clinical
biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of
OConnor John (ROYAL DEVON AND EXETER NHS FOUNDATION
TRUST)
Sent: 06 May 2014 09:44
To: [log in to unmask]
Subject: Amylase vs Lipase ---This message was sent from an email
address external to NHSmail but gives the appearance of
being from an NHSmail (@nhs.net) address. The recipient
should verify the sender and content before acting upon
information contained within. The identified sender is [log in to unmask] CollectiveWhat is the current state of play
re the Amylase vs Lipase debate?.We seem to be getting F2's who
are amazed we are still only offering Amylase as a first
line test for pancreatitis. I do seem to be having more
frequent conversations re relative sensitivity and
specificity and the fact that blanket screening is never a
very good idea and a number is never as good as exercising
good clinical judgement before ordering any test. But alas,
the argument falls on deaf ears.We do test for Macroamylase, plus
have sent the odd sample off for isoenzymes. The only Lipases we do routinely
are for the pancreas/kidney transplant patient as per
the Oxford protocol.Might be a nice topic for an ACB
regional audit, or has this already been
undertaken?.BW JohnBeginning to wonder if the D in my
middle name is starting to stand for Diplodocus
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