Dear Shane,
the others have already given very good examples of "high impact
biology" structures; I would still like to add the structure PDB:1J49
(Razeto et al. (2002). JMB 318, 109).
Its a structure of a D-Lactate dehydrogenase, a two-domain enzyme, where
one ASU subunit adopts an open and the other one a closed conformation -
a very interesting case imho.
Regards,
Fabio
> Date: Mon, 27 Jan 2014 13:08:33 -0500
> From: Shane Caldwell <[log in to unmask]>
> Subject: Examples of multiple ASU copies with different conformations
>
> Hi ccp4bb,
>
> I'm putting together a talk for some peers that highlights strengths and
> weaknesses of structural models for the outsider. For one point, I'd like
> to find some examples of proteins that show very different conformations
> between different copies in the ASU. One example I know of is c-Abl (1OPL),
> which crystallizes with both autoinhibited and active forms in the ASU,
> with dramatically different domain organization. I'd like to find some
> additional examples - can anyone suggest some other structures that have
> multiple copies with large structural variations?
>
> Thanks in advance!
>
> Shane Caldwell
> McGill University
>
>
--
Dr. rer. nat. Fabio Dall'Antonia
European Molecular Biology Laboratory c/o DESY
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