University of Warwick, UK -Systems Biology
Fixed Term Contract for 30 months. Ideally starting Jan-April 2014.
Closing date 5 December.
A postdoc position is available working on an exciting research project applying statistical analysis/modelling techniques to a problem in DNA replication using high-throughput sequence data. During cell division, DNA, a double stranded helix, is duplicated, but the cellular machinery is only able to copy in one direction. The second strand is thus replicated in sections. The aim is to unravel the mechanism and dynamics of this sectioned replication, specifically what affects the location of these sections. Working with a leading biological laboratory generating (next generation) sequence data, your tasks will include analysis and visualization of the data; mapping those sequences to the genome (e.g. using Bowtie/Velvet packages), analysing their distribution; carrying out statistical tests to answer key biological questions; integrate the data with other databases, e.g. correlating with key location markers throughout the genome; interpret the data by discussion with collaborators, and develop models and appropriate fitting algorithms, e.g. constructing bespoke Markov chain Monte Carlo algorithms to analyse the sequence data. You will then determine which models of replication are supported by the data using model selection methods (eg numerical estimation of marginals, Bayes factors).
You should have a PhD in a relevant subject, such as Statistics, Physics, Mathematics, Computer Science, Bioinformatics or similar, should have an interest in biology/biological mechanism and be very enthusiastic about applying statistical techniques to biological data. An ability to program in a high level language is essential (perl, C++, python, R), whilst experience with large sequence data sets is useful. Previous experience with analysis of biological data and collaboration with biologists is highly desirable but not necessary. An understanding of the biology is not expected and training will be given. An ability to write scientific papers/reports and good communication skills with other disciplines is also highly desirable. You should also be ambitious, dedicated and highly motivated.
Applications are through the website
http://www.jobs.ac.uk/job/AHO793/research-fellow/
and must include a full academic CV and a letter outlining your interests, your suitability for the post and what you can bring to it. Please include at least 2 referees whom we can contact. Interviews are expected to take place in December 2013. Enquiries can be made to Nigel Burroughs, [log in to unmask]
This post is funded by BBSRC.
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