JiscMail Logo
Email discussion lists for the UK Education and Research communities

Help for ACB-CLIN-CHEM-GEN Archives


ACB-CLIN-CHEM-GEN Archives

ACB-CLIN-CHEM-GEN Archives


ACB-CLIN-CHEM-GEN@JISCMAIL.AC.UK


View:

Message:

[

First

|

Previous

|

Next

|

Last

]

By Topic:

[

First

|

Previous

|

Next

|

Last

]

By Author:

[

First

|

Previous

|

Next

|

Last

]

Font:

Proportional Font

LISTSERV Archives

LISTSERV Archives

ACB-CLIN-CHEM-GEN Home

ACB-CLIN-CHEM-GEN Home

ACB-CLIN-CHEM-GEN  June 2013

ACB-CLIN-CHEM-GEN June 2013

Options

Subscribe or Unsubscribe

Subscribe or Unsubscribe

Log In

Log In

Get Password

Get Password

Subject:

Re: should we harmonise Ca adjustment formulas first?

From:

Anders Kallner <[log in to unmask]>

Reply-To:

Anders Kallner <[log in to unmask]>

Date:

Tue, 18 Jun 2013 04:51:33 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (1 lines)

Dear Rita,

Don't you think it is about time that the profession stopped using these population based algorithms for individual patients? 

In addition to the innate uncertainty of measuring the ingoing quantities the uncertainty of the algorithm should be considered -as you rightly point out. Furthermore, it is theoretically impossible to go from an average (the algorithm can be viewed as a kind of average) to an individual. You face the same problem as  with the eGFR!

Cheerio,

Anders Kallner



-----Original Message-----

From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Rita Horvath

Sent: den 18 juni 2013 02:46

To: [log in to unmask]

Subject: should we harmonise Ca adjustment formulas first?



David, I do not know the answer to your question but instead I have another question - in fact I asked this from mail base members months ago but received no meaningful answers that I could have summed up. This relates to the adjusted Ca formula: is there any harmonisation achieved on which formula to use for both BCG and BCP albumin methods? In-house formulas (that we also use in my lab for BCP albumin) all suffer from the lack of proper validation and they are dependent on population Ca and albumin data (e.g. my lab mostly serves hospital population and a lot of kids and it is hard to validate our formula e.g. by comparing adjusted Ca to ionized Ca data as the latter test is usually done in critically ill or in those who need blood gas measurements for various acute reasons). So before Pathology Harmony suggests that we shall all use adjusted Ca should we not work on harmonising the Ca adjustment formulas for the various albumin methods? I am sure there is a lot of variation out there...I am also certain that clinicians, using labs which do not provide adjusted Ca results, simply use the old and simple adjustment formula  of Ca+0.02(40-albumin) which is accessible from the web or which allows simple calculations by head. Surely this is not applicable to BCP albumin.



So may I repeatedly ask mail base members of 1/ what Ca adjustment formula your lab is using?

2/ for which albumin method?

3/ and for which Ca method?

4/ Are there any exclusion criteria when the use of the adjustment formula is limited, 5/ and if so what comments do you put on lab reports?



Kind regards, Rita

Prof. Andrea Rita Horvath, MD, PhD, EurClinChem, FRCPath, FRCPA Past President of the European Federation of Clinical Chemistry and Laboratory Medicine Clinical Director, SEALS North, Department of Clinical Chemistry Level 4, Campus Centre, Prince of Wales Hospital Barker Street, Randwick, NSW 2031, Sydney, Australia

Tel: (+612)-9382 9078

Fax: (+612)-9382 9099

Mobile No: (+61)-404 027 843



-----Original Message-----

From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of David Wright

Sent: Tuesday, 18 June 2013 1:09 AM

To: [log in to unmask]

Subject: Calcium Creatinine Clearance Ratio, CCCR



Calcium Creatinine Clearance Ratio is used in the diagnosis of FHH. Currently setting up parameters on the Host computer to make CCCR available. A question to ponder....



Formula (e.g. Hammersmith) appear to use Serum Calcium and not Adjusted Calcium (Pathology Harmonization) in CCCR calculations.

Does using Adj Ca make a significant difference? Does using Adj Ca introduce more error into the calculation (various formulae for Adj Ca) or reduce a potential error (low or elevated albumin levels).



Thanks



David Wright

Lead BMS. Antrim



------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry.

Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content.

ACB Web Site

http://www.acb.org.uk

Green Laboratories Work

http://www.laboratorymedicine.nhs.uk

List Archives

http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html

List Instructions (How to leave etc.)

http://www.jiscmail.ac.uk/



---------------------------------------------------------------------------------------------



Illawarra Shoalhaven Local Health District, South East Sydney Local Health District and Sydney Children's Hospital Network (Randwick Campus) Confidentiality Notice



This email, and the files transmitted with it, are confidential and intended solely for the use of the individual or entity to whom they are addressed. If you are not the intended recipient, you are not permitted to distribute or use this email or any of its attachments in any way. We also request that you advise the sender of the incorrect addressing.



This email message has been virus-scanned. Although no computer viruses were detected, Illawarra Shoalhaven Local Health District, South East Sydney Local Health District and Sydney Children's Hospital Network (Randwick Campus) accept no liability for any consequential damage resulting from email containing any computer viruses.



------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry.

Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content.

ACB Web Site

http://www.acb.org.uk

Green Laboratories Work

http://www.laboratorymedicine.nhs.uk

List Archives

http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html

List Instructions (How to leave etc.)

http://www.jiscmail.ac.uk/



------ACB discussion List Information--------

This is an open discussion list for the academic and clinical community working in clinical biochemistry.

Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content.

ACB Web Site

http://www.acb.org.uk

Green Laboratories Work

http://www.laboratorymedicine.nhs.uk

List Archives

http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html

List Instructions (How to leave etc.)

http://www.jiscmail.ac.uk/

Top of Message | Previous Page | Permalink

JiscMail Tools


RSS Feeds and Sharing


Advanced Options


Archives

March 2024
February 2024
January 2024
December 2023
November 2023
October 2023
September 2023
August 2023
July 2023
June 2023
May 2023
April 2023
March 2023
February 2023
January 2023
December 2022
November 2022
October 2022
September 2022
August 2022
July 2022
June 2022
May 2022
April 2022
March 2022
February 2022
January 2022
December 2021
November 2021
October 2021
September 2021
August 2021
July 2021
June 2021
May 2021
April 2021
March 2021
February 2021
January 2021
December 2020
November 2020
October 2020
September 2020
August 2020
July 2020
June 2020
May 2020
April 2020
March 2020
February 2020
January 2020
December 2019
November 2019
October 2019
September 2019
August 2019
July 2019
June 2019
May 2019
April 2019
March 2019
February 2019
January 2019
December 2018
November 2018
October 2018
September 2018
August 2018
July 2018
June 2018
May 2018
April 2018
March 2018
February 2018
January 2018
December 2017
November 2017
October 2017
September 2017
August 2017
July 2017
June 2017
May 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
August 2016
July 2016
June 2016
May 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
April 2009
March 2009
February 2009
January 2009
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
December 2007
November 2007
October 2007
September 2007
August 2007
July 2007
June 2007
May 2007
April 2007
March 2007
February 2007
January 2007
2006
2005
2004
2003
2002
2001
2000
1999
1998


JiscMail is a Jisc service.

View our service policies at https://www.jiscmail.ac.uk/policyandsecurity/ and Jisc's privacy policy at https://www.jisc.ac.uk/website/privacy-notice

For help and support help@jisc.ac.uk

Secured by F-Secure Anti-Virus CataList Email List Search Powered by the LISTSERV Email List Manager