You are invited to apply for a postdoctoral position in the structural biology lab of McArdle Cancer Institute of University of Wisconsin at Madison. We are interested in understanding the structural basis of protein phosphatase 2A (PP2A) regulation and its cross-talk to cellular and viral kinases in controlling signaling proteins involved in cell cycle, DNA damage response, and cell metabolism. One important aspect of the study is to elucidate mechanisms of protein chaperones in modulating the function of diverse PP2A complexes, kinases and nuclear receptors in response to cellular and environmental signals using structural biology techniques in combination of biochemical and biophysical methods and cell biology approaches. Initial results of this specific aspect of study can be found in our recent publications (Nat. Commun., 4:1699, 2013; Molecular Cell 41, 1–12, 2011).
The lab is equipped with a state-of-the-art setup for x-ray crystallographic studies, including crystallography robot, and have convenient monthly access to powerful x-ray beamlines at APS. The researcher will work in a multidisciplinary setup, including cell biology, biophysics, proteomics, and protein biochemistry, in addition to protein crystallography.
Candidates should hold a PhD in protein biochemistry and crystallography and have a good working knowledge of molecular biology techniques. The candidates should be highly motivated, goal-driven, and dedicated individuals who can think critically and work both independently and collaboratively with good verbal and written communication skills. It is also important that the candidates are creative in problem solving and have a strong desire to seek answers to questions related to the molecular basis of cellular processes. Experience in cell culture techniques and writing scientific research papers would be advantageous. Eligibility to training grant is appealing, but not essential.
This is a full-time position with a starting salary of $39,264 – 44,340 per year depending on skills and experience.
Review of applications will begin immediately and continue until the positions are filled.
To apply: Please send a cover letter, CV and the names and contact information for three references to Dr. Yongna Xing, 1400 University Avenue, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison-Madison, WI 53706. Email: [log in to unmask]
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