FINAL CHANCE TO REGISTER FOR THE FEW PLACES THAT ARE STILL AVAILABLE ON THIS COURSE
PLEASE REGISTER BEFORE FRIDAY NOVEMBER 16TH TO SECURE A PLACE
Phase I and Phase I/II dose finding studies: theory and applications
Presenters:
John O'Quigley, Université Pierre et Maire Curie-Paris VI, Paris, France.
Alexia Iasonos, Memorial Sloan Kettering Cancer Center, New York, USA.
Ken Cheung, Columbia University, New York, USA
The course presenters have broad and varied experience in the area of early phase dose-finding studies. John O'Quigley has published extensively on the statistical methodology of different types of dose-finding designs. After many years experience as a statistician with Bristol Myers Squibb, Alexia Iasonos is now leading the implementation of innovative dose-finding designs at the Memorial Sloan Kettering Cancer Center. Ken Cheung, author of the recent Chapman and Hall text 'Dose finding using the Continual Reassessment Method', has made significant contributions to the statistical literature on this topic. Ken has also overseen the design and analysis of many dose-finding studies in practice.
Date: Tuesday November 20th 2012, 09:00-17:00
Venue: British Medical Association House, Tavistock Square, London (walking distance from St Pancras, Euston and King's Cross)
Agenda
08:30-09:00 Registration, coffee, juice and croissants
09:00-09.10 Welcome and Introduction, Lucinda Billingham
09:10-09:50 General introduction to the methods (3+3, CRM, rolling six, comparative performance), Alexia Iasonos
09:50-10:30 Basic theory to model-based designs (CRM, ADEPT, EWOC, Curve-free, 2-stage designs), John O'Quigley
10:30-10:50 Coffee break
10:50-11:30 How good can a design be? (some misconceptions, some theory, difficulties with 2 parameter models, optimal design benchmark), John O'Quigley
11:30-12:20 Approaches to non-binary outcomes (using information on grades, time-to-event data, continuous outcomes), Ken Cheung
12:20-12:40 Discussion
12:40-13:50 Lunch
13:50-14:40 More complex problems (model averaging, patient heterogeneity, studies of drug combinations, schedules, most successful dose MSD), John O'Quigley
14:40-15:20 Retrospective designs and review of case studies, Alexia Iasonos
15:20-5:40 Tea break
15:40-17:00 Split session A: Statistical theory in practice (convergence, coherence principles, model improvements), Ken Cheung
15:40-17:00 Split Session B: Protocol construction, practical concerns, software availability), Alexia Iasonos
Supported by: MRC Midland Hub for Trials Methodology Research (MHTMR), University of Birmingham
Cost: £180 per delegate (lunch and light refreshment included)
Registration: Online registration is now available by linking to the following site
http://shop.bham.ac.uk/
then follow link: Conferences and Events - Courses and Workshops - Professional Development
For further information please contact Karen Biddle (Senior Administrator for MHTMR) on [log in to unmask]
You may leave the list at any time by sending the command
SIGNOFF allstat
to [log in to unmask], leaving the subject line blank.
|
