Summary of the findings/suggestions so far - thanks again to all who have taken the time and trouble to get in touch.
Question:
Dear All,
I would very grateful for any thoughts about HDL results above 3.5 mmol/L.
Anecdotally we are seeing an increasing number of these results, often with fairly average total cholesterol and low LDL (<2). Does anyone routinely make a comment about these HDL results? Or about the LDL calculation (or remove it)? Is further testing done/recommended? Is this real? Assay interference? Is this protective for the patient?
Best wishes, Lou
Summary:
1. Could you please try to send the samples to any lab that using Denka Seiken Reagent?
Thanks for your reply. Does this reagent go on any type of analyser in a free channel, or is it also a manufacturer of an analyser? I am unfamiliar with this reagent. Is it particularly good for HDL analysis?
Best wishes, and thanks again for your interest.
This reagent can go on any chemistry analyzer in open channel; Randox is the distributor for Denka in USA, not sure in UK,
Denka Company is the one of the main company pioneering the lipids reagent working very close with us since we are specialized in lipids and lipoproteins, their reagent is the best in the market,
2. Since we moved to Roche Cobas c6000 nearly 4 years ago, I regularly see HDL-cholesterol results >3.5mmol/L.
I reported my concerns to Technical Support straight away, during the comparison stages and have not received a satisfactory answer yet. I had been raising it regularly at Roche User Meetings, sorry Roche Symposia, and during our MLS meetings.
I have an enormous amount of cumulative patient data where it cannot be possible for all patients to have changed meds, joined trials, developed liver disease.
I just do not believe the high HDL-cholesterols. Saying that, I do not comment on them and have received no enquiries from our GPs.
3. Raised HDL-C particularly associated with chronic liver disease, especially PBC. Your findings may be linked to increasing chronic liver disease associated with rising alcohol/obesity/diabetes etc.
4. we've done extensive work on this and have a draft paper we are intending to publish. There has been an increase in the % high HDl over a number of years (files attached).
5. Is anyone in your area participating in the REVEAL trial? If so, the increasing numbers could be due to GPs testing patient taking ANAcetrapib. I have a patient whose HDL is 3.1 due to this drug.
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On 14 Sep 2012, at 12:14, Craig Webster <[log in to unmask]> wrote:
> Hi,
>
> I'll try and sort out, my computer is being reinstalled so need to wait for that!
>
> cheers
> Craig
> On 14 Sep 2012, at 12:08, Louise Ward <[log in to unmask]> wrote:
>
>> Hi Craig, I have failed miserably to get these via Athens and our library website, any chance I could be really cheeky and get the pdfs from you?
>> Best wishes, Lou
>>
>> -----Original Message-----
>> From: Webster Craig [mailto:[log in to unmask]]
>> Sent: 14 September 2012 11:49
>> To: Louise Ward
>> Cc: <[log in to unmask]>
>> Subject: Re: Raised HDL
>>
>> Hi Louise,
>>
>> we've done extensive work on this and have a draft paper we are intending to publish. There has been an increase in the % high HDl over a number of years.
>>
>> Heres what we've done so far:
>>
>> http://www.atherosclerosis-journal.com/article/S0021-9150(10)00578-2/abstract
>>
>> http://www.atherosclerosis-journal.com/article/S0021-9150(11)00683-6/abstract
>>
>>
>> Cheers
>> Craig
>>
>> On 14 Sep 2012, at 11:40, Louise Ward <[log in to unmask]<mailto:[log in to unmask]>>
>> wrote:
>>
>> Dear All,
>> I would very grateful for any thoughts about HDL results above 3.5 mmol/L.
>> Anecdotally we are seeing an increasing number of these results, often with fairly average total cholesterol and low LDL (<2). Does anyone routinely make a comment about these HDL results? Or about the LDL calculation (or remove it)? Is further testing done/recommended? Is this real? Assay interference? Is this protective for the patient?
>> Best wishes, Lou
>>
>>
>>
>> Dr Louise Ward FRCPath
>> Clinical Scientist
>> Bedford
>>
>> ________________________________
>>
>>
>> *********************************************************************************************
>> www.bedfordhospital.nhs.uk<http://www.bedfordhospital.nhs.uk>
>>
>> *********************************************************************************************
>> This email is confidential and privileged. If you are not the intended recipient please accept our apologies. Please do not disclose, copy or distribute information in this email or take any action in reliance on its contents; to do so is strictly prohibited and may be unlawful. Please inform us that this email has gone astray before deleting it. Thank you for your co-operation.
>>
>> *********************************************************************************************
>> ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archiveshttp://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/
>>
>
------ACB discussion List Information--------
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