Dear SPMers,
a question regarding circularity: I used a 2x2 design with 2 task conditions (A, B) and two treatment-groups (placebo vs treatment). Using standard procedures I found an interaction effect (Group x treatment) in region X. To further explore whether treatment affected connectivity of region X with other brain regions (the specific target regions were defined using previous findings showing connectivity between region X and the target regions) I want to compare functional connectivity between-groups.
Is it valid to use the coordinates of the maximum t-value from the group x treatment effects to define a seed region for the exploratory connectivity analysis?
Thanks & best regards,
Ben
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