So I was thinking about registering DTI/DWIs to MNI mainly after reading "Connectivity-based segmentation of SN in human and its implication s in Parkinson's Disease" (Menke et. al 2010). Could somebody give me more information on how the DTI/DWIs was registered? At what stage? My main issue is that as far as I know registration protocols use mainly skull but DTI/DWIs images do not have a good skull resolution (I guess it might have to use the b0 images). Also, I know if the DWIs are registered to an MNI space, how could we change the gradient directions as well. I am assuming that when we derive the DTI, this gradient directions will be off if the DWIs have changes orientation to be registered into MNI-space.
Any help or reference to books/literature/etc will help.
Thanks in advance,
Rodrigo
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