No they were not useless! I used them
(probably better now with cryo data though)
Phil
On 6 Jun 2012, at 16:02, Dyda wrote:
>> I suspect that pure MIR (without anomalous) was always a fiction. I doubt that anyone has ever used it. Heavy atoms always give
>> an anomalous signal
>
>> Phil
>
> I suspect that there was a time when the anomalous signal in data sets was fictional.
> Before the invent of flash freezing, systematic errors due to decay and the need
> of scaling together many derivative data sets collected on multiple crystals could render
> weak anomalous signal useless. Therefore MIR was needed. Also, current hardware/software
> produces much better reduced data, so weak signals can become useful.
>
> Fred
>
> [32m*******************************************************************************
> Fred Dyda, Ph.D. Phone:301-402-4496
> Laboratory of Molecular Biology Fax: 301-496-0201
> DHHS/NIH/NIDDK e-mail:[log in to unmask]
> Bldg. 5. Room 303
> Bethesda, MD 20892-0560 URGENT message e-mail: [log in to unmask]
> Google maps coords: 39.000597, -77.102102
> http://www2.niddk.nih.gov/NIDDKLabs/IntramuralFaculty/DydaFred
> *******************************************************************************[m
|