Steve Kent has published a few more (at least 1 other) since HIV...
3ODV http://www.rcsb.org/pdb/explore/explore.do?structureId=3ODV
Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.
Pentelute, B.L., Mandal, K., Gates, Z.P., Sawaya, M.R., Yeates, T.O., Kent, S.B.,
Journal: (2010) Chem.Commun.(Camb.) 46: 8174-8176
_________________________________
Joel Tyndall, PhD
Senior Lecturer in Medicinal Chemistry
National School of Pharmacy
University of Otago
PO Box 56 Dunedin 9054
New Zealand
Skype: jtyndall
http://www.researcherid.com/rid/C-2803-2008
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-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jacob Keller
Sent: Thursday, 16 February 2012 7:36 a.m.
To: [log in to unmask]
Subject: Re: [ccp4bb] surface residue mutation
Right on the money!
JPK
On Wed, Feb 15, 2012 at 12:28 PM, David Schuller <[log in to unmask]> wrote:
> On 02/15/12 12:41, Jacob Keller wrote:
>>>
>>> Are there any all-D proteins out there, of known structure or
>>> otherwise? If so, do enantiomer-specific catalyses become inverted?
>>>
>>> JPK
>>>
> I looked a little harder, and at least one D-enantiomeric protein was
> an
> enzyme:
>
> Total chemical synthesis of a D-enzyme: the enatiomers of HIV-1
> protease show demonstration of reciprocal chiral substrate specificty
> R.C. deL. Milton, S.C.F. Milton, S.B.H. Kent (1992) Science 256(5062)
> 1445-1448.
>
> I guess that answers your question.
>
>
> --
> ======================================================================
> =
> All Things Serve the Beam
> ======================================================================
> =
> David J. Schuller
> modern man in a post-modern world
> MacCHESS, Cornell University
> [log in to unmask]
--
*******************************************
Jacob Pearson Keller
Northwestern University
Medical Scientist Training Program
email: [log in to unmask]
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