I am going to do VBM with the VBM8 extension of SPM8 of a material with > 90 % women (age and sex matched patient and control groups with n = 55 in each) and have some questions:
- Is it best to make my own template given the sex distribution, or can I use the default template?
- I was planning to do the statistics as a paired sample t-test, are there any advantages by doing that instead of a two-sample t-test?
- How do I define the contrasts for a paired sample t-test? I have attached the statistical analysis design for my sample.
I am grateful for any help!