Dear FSL experts,
I am running TBSS to compare 3 groups (26, 19, and 30subjects) and including 2 covariates of age and gender. I generated my matrices with Glm
But I am not sure if it is right.
My design files look like:
Mat file:
/NumWaves 5
/NumPoints 75
/PPheights 1.000000e+00 1.000000e+00 1.000000e+00 8.000000e+01 2.000000e+00
/Matrix
1.000000e+00 0.000000e+00 0.000000e+00 5.500000e+01 2.000000e+00
1.000000e+00 0.000000e+00 0.000000e+00 7.200000e+01 2.000000e+00
....
0.000000e+00 1.000000e+00 0.000000e+00 5.500000e+01 1.000000e+00
0.000000e+00 1.000000e+00 0.000000e+00 7.200000e+01 2.000000e+00
....
0.000000e+00 0.000000e+00 1.000000e+00 6.500000e+01 1.000000e+00
0.000000e+00 0.000000e+00 1.000000e+00 6.600000e+01 1.000000e+00
Con file:
/ContrastName1 "ad_mci"
/ContrastName2 "mci_ad"
/ContrastName3 "ad_hc"
/ContrastName4 "hc_ad"
/ContrastName5 "mci_hc"
/ContrastName6 "hc_mci"
/NumWaves 5
/NumContrasts 6
/PPheights 1.327501e+00 1.327501e+00 1.129511e+00 1.129511e+00 1.290120e+00 1.290120e+00
/RequiredEffect 1.637 1.637 1.187 1.187 1.553 1.553
/Matrix
1.000000e+00 -1.000000e+00 0.000000e+00 0.000000e+00 0.000000e+00
-1.000000e+00 1.000000e+00 0.000000e+00 0.000000e+00 0.000000e+00
1.000000e+00 0.000000e+00 -1.000000e+00 0.000000e+00 0.000000e+00
-1.000000e+00 0.000000e+00 1.000000e+00 0.000000e+00 0.000000e+00
0.000000e+00 1.000000e+00 -1.000000e+00 0.000000e+00 0.000000e+00
0.000000e+00 -1.000000e+00 1.000000e+00 0.000000e+00 0.000000e+00
I have read through the numerous posts on this topic, but I still have some questions:
1. Is my matrics right?
2.Do I need demean the covariates? If so, how to do it? Is it okay when I do randomise with -D option?
Thanks for your help!
Best Regards,
Xiaozhen
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