Hi Stephanie
I can't oblige with a specific example unfortunately, as the only recent
example I have seen looks to be pretty decent quality (fortunately!)
Question: In obese people (BMI ?30 kg/m2) with diabetes who inject
insulin, are 5mm needles, as compared to 8mm, effective at maintaining
glycaemic control and acceptable to patients?
Original paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118929/
Blog post about it here:
http://www.thediabeteself.net/uncategorized/5mm-needles-may-be-as-good-as-8mm-for-obese-patients-with-type-1-diabetes-or-type-2-on-insulin/
However, I was going to suggest that these sorts of examples are a great
resource for all of us, so would you be willing to summarise and share
your findings with the list?
Also, and this may be of interest to the list in general, the CONSORT
group are collating a Library of Examples (of good reporting practices)
in RCTs.
http://www.consort-statement.org/consort-library/
Conflict of interest: I host the above website, though I haven't been
asked by anyone to post this message.
cheers
Douglas
Stephanie Chan wrote:
> Hello all,
>
> I'm preparing a lecture for my housestaff next week on how to read
> noninferiority trials. I would love to hear any examples you may
> recall of flawed noninferiority trials. Examples might include:
>
> -- A trial in which the experimental intervention was found to be
> noninferior to the control, but the noninferiority margin was very wide.
>
> -- A trial in which the intervention was noninferior to the control,
> but the control was little better than placebo.
>
> -- A trial in which noninferiority was found, but there were a large
> number of drop-outs and cross-overs, minimizing any differences
> between the groups.
>
> Thanks for your help and input!
>
> Stephanie
>
>
>
> --
> /Stephanie Chan, M.D./
> http://www.evidencebasedmommy.com/
>
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