Maybe sugars?
El 10/27/11 6:27 PM, Jacob Keller escribió:
> Dear Crystallographers,
>
> In the course of a reasonably smooth refinement, all of a sudden there
> is a huge worm-hole-type blob in the electron density (see pics). Has
> anyone seen this before? Is it some effect of the refinement
> over-fitting or something? For some background, resolution is 2.2Ang
> and there are 4mol/ASU, but one of them is markedly worse in terms of
> density than the rest, and appears to be in a non-crucial part of the
> lattice, as if just sitting in one of the interstices. R/Rfree is
> ~19.5/24.5.
>
> Jacob
>
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Rafael Molina, PhD
Structural Biology and Biocomputing Programme
CNIO - Centro Nacional de Investigaciones Oncológicas
C/ Melchor Fernández Almagro, 3, E-28029 Madrid (España)
www.cnio.es<http://www.cnio.es>
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