Hi Experts,
This is a question on group-level FEAT analysis on a repeated measures design.
I am analyzing a dataset with 2 groups one administered an active drug and another placebo (parallel design) with three measurement time points, 1 baseline (pretreatment) and 2 post-treatment measurements separated by few weeks. My primary interest is the difference between the drug and the placebo group on functional connectivity (seed-based estimated from FEAT). I have the first-level copes for each time point, that I would like to submit to the higher-level group analysis.
The following is what I would like to confirm:
In order to control for baseline differences between the groups I am thinking of using the baseline copes as a continuous voxel-wise EV in the group-level analysis. For clarity, both the post-treatment time points will share the same baseline within a subject. Is this usage acceptable?
Any comments will be greatly appreciated!
Thanks,
Raj
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