Statistics for integrative genomic data analysis

Working at VUmc

The Biostatistics group (see http://www.vumc.com/afdelingen/epidemiology-biostatistics/research/5346018/)<http://www.vumc.com/afdelingen/epidemiology-biostatistics/research/5346018/%29> at the VU university medical center has a very active group of statisticians working on high-dimensional data analysis. The group within the Department of Epidemiology & Biostatistics has close links to the Mathematics and Statistics Department of the VU University Amsterdam, as well as to both the Microarray Facility and the Department of Pathology of the VU university medical center.

Your challenge

The project you will be working on is a case-control study, involving radiation-induced thyroid cancer patients and healthy controls, multiple molecular levels (DNA copy number, methylation, gene expression, and microRNA expression) of the samples have been characterized in high-throughput fashion. From these data, the project aims to develop multivariate statistical models that describe the mechanisms at the molecular level of the cell. This should enhance the understanding of what distinguishes the cases from the controls. The high-dimensionality of the information on and the dependency between the molecular levels make the inference of the molecular mechanisms underlying the distinction between cases and controls a statistical challenge, which is to be tackled within this project. The project is a part of the EU-funded EpiRadBio-project (FP7), which aims to unravel the effects of exposure to radiation on homo sapiens.


Your tasks will be a) the development of multivariate statistical methodology for the analysis of aforementioned data, and b) the analysis of these data, or assist others that do so.

Your profile

You have a PhD in Biostatistics or a closely related discipline. Essentials are:

  *   good statistical knowledge enabling the development of new models and analysis tools,
  *   programming skills,
  *   the ability to explain complex ideas to biologists/non-specialists
  *   affinity with genetics and biology

Previous knowledge of any of the areas involved in the project (such as multivariate statistics, high-dimensional data analysis) and of R programming are an advantage.

Benefits

Salary scale 10: 2459 tot 3899 euro gross when employed full-time (depending on qualifications and experience).

In addition to a good monthly salary, we offer among others, 8,3% extra allowance at the end of the year and 8% for holidays. For more information on our conditions: http://www.werkenbijvumc.nl/werkenbijvumc/watbiedtvumc/

Additional information

The temporary employment will be for a period of 18 months.

Interested?

Would you like more information about the postion, please contact Wessel van Wieringen (PhD), Biostatistician via 0204441047 or Yael O'Callaghan, recruiter via 0204445636. You can apply until 14 oktober 2011 via the following link: http://www.werkenbijvumc.nl/vacatures/D6.2011.00089/


Acquisition regarding this vacancy is not appreciated

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