While it's not a review on protein binding sites, the following review might be helpful in understanding its chemistry:
Holloway & Melnik (1995) Main Group Met. Chem. 451-585.
Also, David Giedroc has written a couple of useful reviews that include discussions of cadmium binding proteins.
Cadmium is kind of a generalist. It will bind to sites tailored for calcium, manganese and zinc quite readily, accepting a wide range of protein ligands. Biologically, most cadmium-specific proteins use softer ligands (cysteines) since other metals are relatively less attracted to those sites. You may see some coordination positions taken up by chloride if you have a high enough concentration in your buffer.
Good luck,
Arthur
On Aug 26, 2011, at 6:54 AM, Sandeep wrote:
> Hi,
>
> I crystallised a protein in the presence of Calcium, Cobalt, and Cadmium and determined its structure. It turns out that I see several metal sites in the structure, mostly cadmiums. Is there any information published (preferably a review) which summarises data on cadmium sites in proteins such as for example the possible coordination numbers of cadmium, distances, type of side chains found to coordinate with cadmium, etc.? I could extract all this from the PDB, but a nice review would be simpler to start with.
>
> Thank you in advance for your help
>
> Sandeep
>
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