Introducing CANDIShare Schiz_Bull_2008 Version 1.1. With this release
we have added the CMA 'general' segmentation for all 103 subjects in
the prior Schiz_Bull_2008 V1.0 release.
Get it now at: http://www.nitrc.org/projects/candi_share
We include the preprocessed MRI images and CMA 'general' segmentation
results of all 4 diagnostic groups (Healthy Controls (N=29),
Schizophrenia Spectrum (N=20), Bipolar Disorder with Psychosis (N=19),
and Bipolar Disorder without Psychosis (N=35)) from the article:
Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM,
Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B,
Makris N. Diagnostic and sex effects on limbic volumes in early-onset
bipolar disorder and schizophrenia. Schizophr Bull. 2008
Jan;34(1):37-46.
The release contains 4 files, one for each diagnostic group, provided
as a gziped tar file of a set of directories containing the data.
The root directory is for the paper, SchizBull_2008/, and contains
subdirectories for the 4 diagnostic groups: Healthy Controls (HC),
bipolar disorder without psychosis (BPDwithoutPsy), bipolar disorder
with psychosis (BPDwithPsy) and schizophrenia spectrum (SS). Each of
these subdirectories will contain separate subdirectories for each
subject. These subject directories contain the CMA preprocessed image
that was submitted to the anatomic segmentation process, and the
results of the general segmentation. These files are of type NIfTI
(nii.gz) and called {$SUBJECT_ID}_{$TYPE}.nii.gz; where $TYPE is
'procimg' for preprocessed images, and 'seg' for general segmentation.
The seg results are 'n-ary' images, where the fill value represents
the specific anatomic region.
Each of the diagnostic group tar files will 'unpack' onto the same
directory structure and fill in the released subset of data.
The nature of the CMA preprocessing includes positional normalization
to put the image into the standard orientation of the Talairach
coordinate space, and bias field correction as described in: Worth AJ,
Makris N, Patti MR, Goodman JM, Hoge EA, Caviness VS Jr, Kennedy DN.
Precise segmentation of the lateral ventricles and caudate nucleus in
MR brain images using anatomically driven histograms. IEEE Trans Med
Imaging. 1998 Apr;17(2):303-10.
The basic segmentation procedures followed by the CMA are overviewed
in: Filipek PA, Richelme C, Kennedy DN, Caviness VS Jr., The young
adult human brain: an MRI-based morphometric analysis. Cereb Cortex.
1994 Jul-Aug;4(4):344-60.
Diagnostic group basic demographic information is provided in the
diagnostic subdirectory in a .csv file entitled
{$DIAG}_Basic_Demographics.csv. This file contains age, gender, and
handedness for each of the subjects in the diagnostic group.
The fill value codes for the 'seg' files can be found in the
'seg_fill_values.txt' file to be found in the Documents section of the
CANDIShare NITRC project. The fill values are correct for automatic
interpretation using the 'CMA Subcortical' color pallet in fslview and
the Freesurfer 'FreeSurferColorLUT.txt'.
Enjoy!
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