> Specifically, the reviewers question whether ripples may affect on the
> electron density around heavy metal center which has a Mo-S-As
> connection. From which angle or in which way this problem should be
> addressed most convincingly ?
The maximum entropy estimate of the map should be insensitive to series
termination errors, and would thus answer the referee's concerns. You
could give it a try with the program 'graphent' which can read mtz files
and produce ccp4 map files.
Whether the referee considers maximum entropy methods 'convincing' remains
to be seen ... ;-)
Dr Nicholas M. Glykos, Department of Molecular Biology
and Genetics, Democritus University of Thrace, University Campus,
Dragana, 68100 Alexandroupolis, Greece, Tel/Fax (office) +302551030620,
Ext.77620, Tel (lab) +302551030615, http://utopia.duth.gr/~glykos/