I changed the bounding box and it works - many thanks for your help! And you're right, of course, it's the Crinion-paper. And thanks for the other reference (Andersen et al 2010). As I am drawing lesion masks anyway (in MRIcron), I will give it a try. Do you know whether I just can use the "Create SPM5 masks" option in MRIcron for masking the lesion in SPM8? It creates two files (mwxi.nii and lwxi.nii), I guess I have to use mwxi.nii?