we are currently doing a fMRT analysis in SPM8. The preprocessing of our images consists of realignment, slice timing, normaization to the EPI-template and smoothing.
When we checked the results by overlaying the EPI-template with the activation maps after preprocessing in MRIcro we noticed that for all the subjects there seems to be a consitent lack of activation in certain regions.
The images attached are typical for all subjects analized. As you can see there seems to be a "hole" in the activation in the temporal lobe (bilateral, upper images) and in the inferior frontal lobe (lower images). The size of these gaps in activation seems to differ slightly across the subjects, but the general pattern is pretty consistent.
It would be very nice if you could give me insight what went wrong with the preprocessing and help solve this problem. IF needed I can of course provide additional info regarding the parameters used.
Thanks in advance for any input!