Reply-To: | | [log in to unmask][log in to unmask]> wrote: >> >>> I agree that nuisance covariates, such as motion should be removed; >>> however, motion covariates are not generally stored in X0 in my >>> reading of the SPM code (spm_fMRI_design, spm_regions). They should be >>> removed in the spm_regions filtering based on the null-space of the >>> contrast. >>> >>> As for the motion parameters being in the model, if they were in the >>> standard analysis, they should be included in the PPI analysis. My >>> gPPI code will do this automatically as well. >>> >>> X0 is made of SPM.xX.iB (block effects -- so removing the mean) and >>> SPM.xX.iG (nuisance variable that is empty as far as I can tell (line >>> 369 of spm_fMRI_design)) and the high-pass filtering (K.X0). >>> >>> Best Regards, Donald McLaren >>> ================= >>> D.G. McLaren, Ph.D. >>> Postdoctoral Research Fellow, GRECC, Bedford VA >>> Research Fellow, Department of Neurology, Massachusetts General >>> Hospital and Harvard Medical School >>> Office: (773) 406-2464 >>> ===================== >>> This e-mail contains CONFIDENTIAL INFORMATION which may contain >>> PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED >>> and which is intended only for the use of the individual or entity >>> named above. If the reader of the e-mail is not the intended recipient >>> or the employee or agent responsible for delivering it to the intended >>> recipient, you are hereby notified that you are in possession of >>> confidential and privileged information. Any unauthorized use, >>> disclosure, copying or the taking of any action in reliance on the >>> contents of this information is strictly prohibited and may be >>> unlawful. If you have received this e-mail unintentionally, please >>> immediately notify the sender via telephone at (773) 406-2464 or >>> email. >>> >>> >>> >>> On Wed, May 4, 2011 at 10:16 PM, Alex Fornito <[log in to unmask]> >>> wrote: >>>> Hi Donald, >>>> Thanks for your response. When you say "you don't want >>>> to filter out anything related to neural activity", I'm presuming that you >>>> are referring to the deconvolved neural signal? >>>> >>>> If so, that makes sense. However, X0 also contains user-specified nuisance >>>> covariates. I would have thought it would make sense to remove those, >>>> depending on what they were (e.g., movement parameters)? I guess they can >>>> always be entered into the PPI regression model... >>>> >>>> >>>> On 05/05/2011 11:57, "MCLAREN, Donald" <[log in to unmask]> wrote: >>>> >>>>> I could be wrong, Karl or Dar%Â\:p |