Dear Henry,
This one is actually correct, I think. pyroglutamic acid has an internal
amide, and the only reactive group is the acid group. When that is
involved in a link (as it is, for 'start') there is nothing left to
protonate or deprotonate.
Yours,
Rasmus
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Dr. Rasmus H. Fogh Email: [log in to unmask]
Dept. of Biochemistry, University of Cambridge,
80 Tennis Court Road, Cambridge CB2 1GA, UK. FAX (01223)766002
On Fri, 18 Mar 2011, Henry Hocking wrote:
> Dear developers,
>
> I noticed that pyroglutamic acid (Ccp Code Pca) exists only in neutral
> form when it's 'Polymer linking' is 'start'. Shouldn't there be an option
> for 'prot:H1' at this position?
> Kind regards,
>
> Henry
>
>
>
> --------------------------------------------------------
> Henry Hocking, PhD
>
> Utrecht University
> Bijvoet Center for Biomolecular Research
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