Dear FSL experts,
I have a methodological question about temporal-concatenated ICA. I have
performed a TC-ICA in a sample of 26 subjects with a psychiatric illness,
15 subjects in remission from the same illness and 24 controls. If the
hypothesis is to find some network dysfunction correlated with the risk of
this illness, this sample is biased by an excess of 'cases' in comparison
to 'controls'. Is there some rule in the sample composition when using
TC-ICA (and then dual regression to compare groups)? do I need to use
samples with the same number of cases/controls?
In other words, how much the composition of the sample can affect the
'quality' of extrapolated networks? Is it correct to perform TC-ICA in
homogeneous samples (only cases, only controls) to do a 'descriptive'
analysis of network functioning/variation in a pathological sample?
Thank you for any advice!
Angela
Angela Favaro, MD, PhD
Psychiatric Clinic
Department of Neurosciences
via Giustiniani 3
35128 Padova
Italy
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