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SPM  February 2011

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Subject:

Re: Interpret pediatric fMRI

From:

Marko Wilke <[log in to unmask]>

Reply-To:

Marko Wilke <[log in to unmask]>

Date:

Fri, 18 Feb 2011 16:57:24 +0100

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text/plain

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Hi Ghazal,

> fro the mailing list I understood that there had been a few of you having the same question as mine, however I couldn't get an exact answer to it.

That may be because there is no exact answer :)

> I am using TOM template to create a group specific template based on the data from NIH study (that I suppose works the best for a group of 42 8-11 year old children). and I used that template in normalization step during preprocessing. it goes without saying that there is no meaningful dependence or relation between this template and the known template for adults (e.g. MNI template) and it makes the interpretation of the activation spots quite tricky!! since I cannot use the coordinates given by SPM and look them up in available brain atlases to find the anatomical point for activation. (as  these atlases are all based on adults brains)

I agree: the whole point of using a custom template is to be have more 
appropriate reference data for your group under study. When using such a 
template, you bring the images into (in SPM's case) MNI space, but they 
are not necessarily in alignment with the templates that were used to 
generate automatic lookup-helper-applications (although they may not be 
very far off, either). Note that this issue is by no means one of the 
TOM approach but will apply to each and every study using customized 
templates. I see that the famous Good et al paper (NI 2001) has been 
cited about 1500 times, and if all of them used the there-described 
approach to creating a custom template... you get my point.

> sop how can I report about the anatomical point of activation. i am not very good at anatomy too look at the activity and guess the name of that point. even if I was that wouldn't be scientifically accepted I suppose

I agree that guessing is not a good idea but I do not see why it should 
not be scientifically acceptable to use your eyes. Actually, I think 
that it may be less scientific to feed a long row of numbers into an 
algorithm and take the results at face value without checking at least 
some of them, using common sense and an anatomy textbook. The good thing 
is that the images may speak for themselves, so including representative 
slice that allow the reader to assess the localization goes a long way 
(you should still be able to name the structures involved, though :). I 
have written long paragraphs in a number of revisions, not all of them 
successful, trying to convey may unwillingness to include a table of 
activation foci, because, yes, this makes meta-analyses harder. But it 
is a compromise, and somehting's got to give.

Cheers,
Marko
-- 
____________________________________________________
PD Dr. med. Marko Wilke
  Facharzt für Kinder- und Jugendmedizin
  Leiter, Experimentelle Pädiatrische Neurobildgebung
  Universitäts-Kinderklinik
  Abt. III (Neuropädiatrie)


Marko Wilke, MD, PhD
  Pediatrician
  Head, Experimental Pediatric Neuroimaging
  University Children's Hospital
  Dept. III (Pediatric Neurology)


Hoppe-Seyler-Str. 1
  D - 72076 Tübingen, Germany
  Tel. +49 7071 29-83416
  Fax  +49 7071 29-5473
  [log in to unmask]

  http://www.medizin.uni-tuebingen.de/kinder/epn
____________________________________________________

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