Dear harvey
Consider your purification and preparation protocols - is the sample pure and homogenous?
Poul
On 21/02/2011, at 03.29, Harvey Rodriguez <[log in to unmask]> wrote:
> Dear CCP4BBers,
>
> Recently I got a crystal which appeared in the condition 2.1M DL-Malic Acid, pH 7.0. The crystal looks like a dumbbell but was composed of a cluster of very thin needles as shown in the picture. The crystal can be repeated but the diffraction is poor. I have tried the grid optimization by pH and salt concentration gradients, however there was no improvement in either the shape or the quality of the crystal. Does anyone have some experiences in optimizing this kind of crystals? Any suggestion is appreciated!
>
> Harvey
> <dumbbell crystals.jpg>
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