On Jan 17, 2011, at 11:46 AM, James Holton wrote:
>
> I am willing to bet that the earliest "no method" entries (particularly the ones that lack a REMark 200 record) were probably MIR, since that was the "obvious" method to solve a structure for some time. Modern "NULL" entries seem to be mostly what I call "molecular replacement", which includes just refining from a native, etc. not necessarily running an MR search program.
I was taught to refer to this method of solution as "isomorphous replacement," as long as the space group and/or unit cell had not changed so much that rigid body refinement could not lower the free R-factor enough for conventional refinement to proceed.
Diana
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Diana R. Tomchick
Associate Professor
University of Texas Southwestern Medical Center
Department of Biochemistry
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