Dear SPMers,
we are planning a psychopharmacological-fMRI study (placebo controlled). Participants should perform two similar working memory tasks while in the scanner. Would it be possible to use the first task to functionally define the working memory networks and then restrict the analysis of the second working memory task to these functionally defined rois?
My idea is to perform a second level 1-sample t-test on the first level contrast for:
Working memory task 1: active condition > control condition
Clusters surviving the threshold from this task represent the working memory networks and serve as Rois for the analysis of the second working memory task. The rois will be used to extract %-signal change for the contrast active > control in the second working memory task.
Thanks in advance & best regards
Ben
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