***********Director of Eukaryotic Protein Production*************
We seek a Director of Eukaryotic Protein Expression within the Macromolecular
Therapeutics Development Facility (MTDF) at the Albert Einstein College of
Medicine. The MTDF runs a high-throughput pipeline including automated cloning,
expression and purification, as well as an active program focused on the
development of novel protein expression/purification strategies in both
prokaryotic and eukaryotic hosts. Our existing platforms support individual
investigator initiated programs at Einstein and the greater New York Area, as
well as a number of large-scale multi-institutional structural and functional
genomics programs. The MTDF currently serves as the protein production core for
both the New York Structural Genomics Research Consortium (NYSGRC), one of four
high-throughput structure determination centers supported by the NIGMS Protein
Structure Initiative, as well as the Enzyme Function Initiative, a large-scale
NIGMS-supported program developing a general sequence/structure-based strategy
for the discovery of enzyme function. The MTDF also serves as the eukaryotic
expression core for the Northeast Biodefense Center, an NIAID Center of
Excellence in biodefense and emerging infectious disease research, and supports
the Immune Function Network which focuses on the structural and functional
genomics of the innate and adaptive immune responses. In addition, the MTDF is
establishing a high-throughput lentiviral-based shRNA screening core and will
make available new technologies related to the use of RNA interference to
investigators at the Albert Einstein College of Medicine and other institutions
in the New York area.
We are seeking an exceptional individual for the position of Director of
Eukaryotic Protein Expression to oversee the day-to-day operations of protein
production and technology development programs. Specific duties include the
oversight and further development of high-throughput platforms for eukaryotic
expression, including the use of transiently and stably transfected Drosophila
S2, CHO and HEK293T cell lines, as well as baculoviral- and lentiviral-driven
expression systems. Additional efforts will focus on the creation and
implementation of novel high-throughput approaches for eukaryotic expression.
A Ph.D. and at least four years of experience in eukaryotic protein expression
is strictly required, as is previous experience with automation and robotics.
As a significant element of our developing platform relies on baculoviral- and
lentiviral-driven expression, previous experience with viral-based vectors,
viral packaging and large-scale viral particle production is highly desirable.
The successful candidate will have strong organizational capabilities and the
interpersonal skills required to interact with the leaders and members of a
broad range of different research programs. The ability to work independently,
and to supervise and manage multiple projects simultaneously is essential. Team
membership skills are particularly important to ensure that these activities
seamlessly integrate with the established programs, investigators and
leadership within the MTDF.
The successful candidate will be appointed to a non-tenure track faculty
position at the level of Associate. Salary is commensurate with experience and
accompanied by a broad range of employee benefits. The Albert Einstein College
of Medicine provides a highly stimulating academic environment and assures
equal employment opportunities.
Interested candidates should forward a cover letter (describing training,
background and accomplishments), curriculum vitae with bibliography and the
names and contact information of three references to Dr. Ron Seidel, Associate
Director, MTDF (rseidel_at_aecom.yu.edu) or Dr. Steve Almo, Scientific
Director, MTDF (almo_at_aecom.yu.edu).
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