the Young Statisticians Section of the Royal Statistical Society would like to bring the following meeting to your attention
14th October 2010,
RSS Joint Meeting West Midlands & Young Statisticians Section
RSS Local Group meeting, University of Warwick,
17:00 - 19:00
5.00pm – 5.30pm: tea
5.30pm – 6.00pm: Mouna Akacha (Warwick University)
Missing Data in Longitudinal Studies: A Review
In clinical trials it is very common for sets of repeated measurements to be incomplete. In this talk we will give a review on potential problems that arise with missing data and on methods to handle missing data. We will discuss the underlying assumptions and limitations of these approaches. Finally, we will illustrate the challenges we encountered in analyzing two clinical trials with missing data.
6.00pm – 7.00pm: James Carpenter (London School of Hygiene and Tropical Medicine)
Assessing the sensitivity of meta-analysis to selection bias: a multiple imputation approach
Evidence synthesis, both qualitatively and quantitatively through meta-analysis, is central to the development of evidence-based medicine. Unfortunately, meta-analysis is often complicated by the suspicion that the available studies represent a biased subset of the evidence, possibly due to publication bias or other systematically different effects in small studies. A number of statistical methods have been proposed to address this, among which the trim-and-fill method and the Copas selection model are two of the most widely discussed. Here, we adopt a logistic selection model, and show how treatment effects can be rapidly estimated via multiple imputation. We illustrate our approach using a small meta-analysis of benign prostatic hyperplasia.
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With best wishes,
On behalf on the Young Statisticians Section, Royal Statistical Society
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