The Institute of Cancer Research
(University of London)
Section of Structural Biology
Chelsea, London
Post-doctoral Training Fellows
Structural Biology of proteins involved in DNA repair
Postdoctoral positions are available to join a team in the laboratory of
Prof. Dale Wigley, FRS, who has recently relocated to the Institute of
Cancer Research. The project will be to study the structure and mechanism of
proteins involved in DNA double-strand break repair, a key aspect in the
prevention of cancers. Studies will include the bacterial RecBCD and AddAB
complexes as well as the human DNA double-strand break repair complexes,
several of which are already expressed and purified. The postholder/s will
will join a team of international scientists with a diverse range of
structural and biochemical expertise working closely together and will be
responsible for expression, purification, crystallization and structural
analysis of proteins and protein complexes either by crystallography or
electron microscopy.
The Institute of Cancer Research (a College of the University of London) is
a world-class cancer research organisation. The Section of Structural
Biology at ICR is exceptionally well equipped for all aspects of modern
structural biology, with state-of-the-art laboratories for molecular
biology, recombinant expression in bacterial and eukaryotic systems,
biochemistry, X-ray crystallography and electron microscopy. Excellent
synchrotron access (~ 2 days per month) is available through rolling beam
allocation programmes at Diamond and ESRF.
Applicants should hold a PhD in a biological, chemical or physical science,
have experience of macromolecular crystallography and recombinant protein
expression, and evidence of a good publication record. Experience in
determining structures by MIR or MAD, or of single particle electron
microscopy would be an advantage.
The starting salary will be in the range £26,996 to £32,024 p.a. inclusive
(based on previous post-doctoral experience) and posts will be offered on 3
year fixed term contracts initially.
For further particulars and details of how to apply, please visit our
website at www.icr.ac.uk <http://www.icr.ac.uk> . Alternatively you may call
our 24 hour recruitment line on 020 7153 5475 quoting job reference number
C370.
Closing date: 31st October 2010
This communication is from Cancer Research UK. Our website is at www.cancerresearchuk.org. We are a registered charity in England and Wales (1089464) and in Scotland (SC041666) and a company limited by guarantee registered in England and Wales under number 4325234. Our registered address is 61 Lincoln's Inn Fields, London WC2A 3PX. Our central telephone number is 020 7242 0200.
From 1 October 2010 our registered address will be Angel Building, 407 St John Street, London, EC1V 4AD.
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