HI,
I have conducted TBSS on 9 patients and their age and gender matched controls. I have then used the randomise tool to obtain voxelwise statistics on the skeletonised FA data.
Contrast 1 gives me controls>patients, see yellow/red.
Contrast 2 gives me controls<patients, see blue/light blue.
The image is at the address below as I could not get it small enough to attach it to this email.
http://www.admanltd.com/facomparison.jpg
All are overlaid on the FA skeleton (see green)
Although my patients suffer from a chronic condition, it is NOT a degenerative disease, so I am interested in both contrasts.
I was very surprised (disappointed) when I looked at Contrast 2. What could have happened that there are sooo many regions in the patients (look at blue/light blue) that are "increased" relative to the controls?
Any suggestions are very welcome,
I could have made a mistake, I am an FSL novice, subject numbers? I am fishing.....
In advance
Thank you for your time and thoughts.
Uta
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