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CCP4BB  July 2010

CCP4BB July 2010

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Subject:

Re: non-symmetric tetramer ?

From:

Miri Hirshberg <[log in to unmask]>

Reply-To:

Miri Hirshberg <[log in to unmask]>

Date:

Thu, 29 Jul 2010 08:53:09 +0100

Content-Type:

TEXT/PLAIN

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TEXT/PLAIN (36 lines)

Thurs., July 29th 2010
EBI

Morning,

I think Andrew meant PDB 2gd1 and 1gd1 (has 4 NAD)
DOI    10.1016/0022-2836(88)90130-1

Miri

On Wed, 28 Jul 2010, A Leslie wrote:

> Hi Fred,
>
>        If your tetramer show negative cooperativity between the 4 sites for 
> ligand binding, then it is possible to get a tetramer with (say) only one 
> subunit occupied by ligand, which can introduce considerable asymmetry if 
> ligand binding gives rise to a  hinge type closure of two domains around the 
> ligand site. An example of this is glyceraldehyde 3-phosphate dehydrogenase 
> which has been solved with one, two (and possibly 3) NADs bound per tetramer. 
> I'm afraid you will need to do a literature search to find the references, 
> but AJ Wonacott will be one of the authors.
>
> Cheers
>
> Andrew
>
>
> On 28 Jul 2010, at 19:31, Fred wrote:
>
>> Dear CCP4bb,
>> Could someone please, point me to some references about non-symmetric 
>> tetramers? If I have a tetramer composed by 4 identical subunits, it'll 
>> always have a P4 point group symmetry?
>> Thank in advance,
>> Tomb

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