A CASE studentship, funded by EPSRC under the Knowledge Transfer
Network, is available in the Design and Analysis of Clinical Trials in
Pharmacogenetics. This will be jointly supervised by Prof Stephen Senn
(Department of Statistics, Glasgow) and Dr Vladimir Anisimov (Research
Statistics Unit, GlaxoSmithKline).
Spectacular advances in molecular genetics, gene sequencing and
genotyping over the last few decades have raised the hope that clinical
investigations of pharmaceutical remedies for disease can be made more
efficient and more effective by targeting subgroups of patients that
have the greatest ability to respond to treatment. However, there are
many ways of subgrouping patients, random variability is high, is
affected by the type of randomization, stratification level and
recruitment scheme and in consequence developing promising targeted
therapies has been difficult. In this project, approaches to designing
drug development programmes and clinical trials capable of efficiently
resolving components of variation and effectively identifying gene by
treatment interactions will be developed.
The successful candidate will have a first degree in a quantitative
subject such as statistics. Some knowledge of genetics will be an
advantage. There is a stipend enhancement of 4000 pounds above the
usual EPSRC rate.
Please contact Stephen Senn [log in to unmask] if interested
Stephen Senn
Professor of Statistics
Department of Statistics
Direct line: +44 (0)141 330 5141
Fax: +44 (0)141 330 4814
Private Webpage: http://www.senns.demon.co.uk/home.html
University of Glasgow
15 University Gardens
Glasgow G12 8QW
The University of Glasgow, charity number SC004401
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