When I extracted my seeds, I did not adjust the VOI for the effects of
interest. However, I still see rather substantial PPI effects (surviving FWE
corrections). Is the analysis incorrect if you do not adjust the VOI
extraction, or is it just noisier?
Also, does it make sense to use a region that "deactivates" as a seed? If
so, is the interpretation the same (seed fit to time series is better in one
condition then the other)