Dear Connie
That's tricky as it seems to be three questions:
1. Are small studies enough (predicting the results of large studies)?
2. Do short term outcomes predict long term outcomes?
3. Are results from one setting generalisability across other settings
and patients?
Each of those is a major topic, but a generic start might be John
Ioannidis essay "Why most published research findings are false." PLoS
Med. 2005 Aug;2(8):e124. Epub 2005 Aug 30.
and its reference 36.
Best wishes
Paul Glasziou
Connie Schardt wrote:
> I've got a question from one of our EBM instructors:
>
> He's looking for an article/commentary that concludes that one small study
> in a specific population for a short amount of time is not adequate for
> making claims that everybody will see these effects over long periods of
> time.
>
> Anyone have a reference for this?
>
> Thanks,
>
>
> Connie
>
> Connie Schardt
> Medical Center Library
> Duke University
>
>
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