Two POSTDOCTORAL POSITIONs to study macromolecular complexes and signaling are open at the Department of Biomolecular Mechanisms at the Max Planck Institute for Medical Research, Heidelberg. The highly interdisciplinary department focuses on understanding reaction mechanisms using crystallographic analysis of reaction intermediates with a strong emphasis in physical biochemistry. Detailed information can be found at: http://wbmm.mpimf-heidelberg.mpg.de 

 

Project 1: Macromolecular complexes in RNA maturation

Posttranscriptional RNA processing is accomplished by a huge macromolecular complex, the cleavage / polyadenylation machinery, which harbors several enzymatic activities such as RNA cleavage and RNA polyadenylation activities. Regulation of this machine is required for proper and the incorporated enzymes are triggered by their interacting partners. We study the assembly pathway and the architecture of the Cleavage Factor I from yeast and its mammalian homologues, a stable and rigid subcomplex of the cleavage / polyadenylation machinery. In particular, we are interested in how the 5’-kinase Clp1 is switched on and off within the large macromolecular machine.

 

Project 2: Blue light regulated photo-receptors 

Photo-receptors are light sensitive switches that exist in ON and OFF states that (in)activate associated effectors via a structural change. Like for every mechanical device, knowledge of its architecture and the changes occurring during function helps to understand and to rationally modify the switch. We are studying light-dependent phosphodiesterases, cyclases and transcription factors biochemically and structurally. Future applications of these systems for cellular or neurobiological applications are intended. The projects are at various experimental stages, so that the successful candidate can start productive work immediately.

 



We are looking for highly motivated candidates with a strong background in X-ray crystallography who can interact collaboratively among a variety of disciplines. The successful candidates must have at least one first-author publication describing a de-novo structure determination. Experience with eukaryotic cell culture is advantageous. We offer a highly stimulating interdisciplinary and international research environment, excellent working conditions and facilities, including regular access to synchrotrons. The positions are initially for two years, but have longer term perspective, given excellent performance. There are possibilities to join other ongoing exciting structural projects of high scientific impact. 

 

To apply, please send a CV including a brief description of your research/scientific interests, a list of publications, a copy of the most relevant publication, and names and email addresses of two referees either as email attachments to

[log in to unmask] <mailto:[log in to unmask]>, indicating the keyword REC2010 in the subject line.

 

Informal enquiries may be sent to

Anton Meinhart ([log in to unmask] 
<mailto:[log in to unmask]>) for project 1

Ilme Schlichting ([log in to unmask] 
<mailto:[log in to unmask]>) for project 2


Deadline for applications is April 15 th, 2010, desired starting date is 
as soon as possible.