Hello,
I am curious if anyone here has done a voxel-wise PVC on BOLD fMRI data
before. I am familiar with PVC in SPECT, PET, and ASL perfusion
measurements, but have not heard it done with BOLD data. A reviewer recently
criticised a proposal of ours for not having a protocol for voxel-wise PVC
of BOLD data, and I am stumped trying to find any reference to methods for
doing this.
We are not using standard space for analysis but rather the 'functional ROI'
method of localizing a region in individuals in native space. The issue is
the anatomical structure where the fROI is localized may be a different size
between our two populations.
Any thoughts or points in the right direction would be greatly appreciated!
My final niggling thought is: is PVC of BOLD even necessary when the
activation maps are difference images between two different activation
states (e.g., extrastriate cortex looking at house v objects)? I think this
is a different creature from resting glucose metabolism images from a PET
scanner, where less tissue looks like hypometabolism, as in BOLD data we
wouldn't expect CSF voxels to show significant changes in activity with two
activation states anyway.
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