Curious term indeed.
However, a bit of digging turned up this gem. Fong and Lam "HPLC in the pharmaceutical industry" state that "For practical purposes, orthogonal methods can be conceived to be methods that differ substantially in a mechanistic sense from those used for purification or for process optimisation" (p284).
My guess, then, is that generally methods are orthogonal if they have no or little commonality in how they measure an analyte (e.g. creatinine by LC/MS vs. Jaffe reaction). Doesn't make them reference methods per se, but goes some way to meetnig the requirement for verification by different technologies.
Best wishes,
Dave
Dr David Hardy,
Senior Scientist,
Drug Safety R&D,
Pfizer Ltd,
Sandwich
________________________________
From: Clinical biochemistry discussion list on behalf of David Brown
Sent: Sat 05/12/2009 17:17
To: [log in to unmask]
Subject: Re: Orthogonal method
Freelance translators never sleep,
In what context, James?
I have come accross this in my translation work. It was used to assess the individual components of a Quality of Life Questionnaire, in obesity.
If it is the same thing it also appears to come under the name of orthogonal principle component analysis
Regards
David
David G Brown
Valencia
Espaņa
--- On Sat, 5/12/09, James J Miller <[log in to unmask]> wrote:
> From: James J Miller <[log in to unmask]>
> Subject: Orthogonal method
> To: [log in to unmask]
> Date: Saturday, 5 December, 2009, 16:52
>
>
>
>
> In case some of you are working like me and not out
> having a good time on this weekend, can anyone enlighten me
> on any specific meaning or nuances for the term
> "orthogonal method"? It's use in what I
> am reading clearly means "reference method", but
> why "orthogonal"? I understand the word
> "orthogonal" in general. I have found the
> term "orthogonal method" used in the literature,
> but nothing in clinical laboratory medicine. I found
> the term used on an IFCC document, but it was not defined
> and the context seemed to be related to basic
> biochemistry. I have found no peer reviewed
> publication that uses the term and I cannot find it on the
> NIST web site.
>
> Is there some subtle nuance to the term or does it
> simply mean "reference method."
>
> Thanks. -Jim, Louisville, Kentucky, USA
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