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Postdoctoral Research Fellow
Druggability of Protein-Protein Interactions by Fragment-Based Methods
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Applications are invited for a full-time postdoctoral research scientist at the University of
Cambridge.
Postdoc Job Description:
We are looking for a highly motivated postdoctoral research fellow to join our laboratory.
We are interested in developing novel fragment-based strategies to investigate the
druggability of protein-protein interfaces with respect to modulation by small molecules,
and implications for drug design. The project will involve applying a combination of
protein engineering and biophysical and structural techniques to study protein-ligand and
protein-protein molecular recognition, including protein X-ray crystallography, NMR
spectroscopy, isothermal titration calorimetry and surface plasmon resonance. For a
review and a recent example of our fragment-based approach see Curr. Opin. Biotech.
2007, 18(6), 489-496 and Angew. Chem. Int. Ed. in press,
http://dx.doi.org/10.1002/anie.200903821.
The successful candidate will have the opportunity to join the Cambridge Molecular
Therapeutics Programme (see http://www.cmtp.cam.ac.uk/CMTP_intro.html), an
interdisciplinary initiative based at Cambridge to explore new strategies for the discovery
and development of drugs against disease such as cancer and tuberculosis. The
laboratories are exceptionally well equipped with state-of-the-art equipment for all
aspects of modern chemical and structural biology.
Qualifications:
Successful candidates should have (or be about to receive) a PhD in Chemistry,
Biochemistry, Structural Biology, or a related area. Experience in molecular biology,
protein purification and with appropriate biophysical techniques is essential; some
experience in synthetic organic chemistry would be advantageous. The ability to work in a
creative, interdisciplinary and dynamic research environment at the interface of chemical
biology and drug discovery is paramount. Good written and oral communication skills are
essential.
Procedure to Apply:
Please send your CV, publications list, and contact details for three professional referees
to Dr Alessio Ciulli, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW
(email: [log in to unmask]). Further information can be found at
http://www.ch.cam.ac.uk/staff/ac.html.
Vacancy Reference No: MA05715.
The post is available from 1st January 2010, for up to 5 years in the first instance.
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