Dear colleagues,
Please find details below of a one hour-long, educational web tutorial relating to complex randomisation solutions in clinical trials of many treatments. The talks will be given from a scientific viewpoint – they will not be Company promotional. A statistical background is not required so please pass on to study team colleagues.
Times are
Tuesday, September 15, 2009— 3.00 pm UK; 4.00pm CET; 5.00pm EET; 10:00 am. EST
Thursday, September 17, 2009—6.00pm UK; 7.00pm CET; 8.00pm EET; 1:00 pm. EST
http://www.perceptive.com/News/Webinars/Webinar-Registration.html?webcast_id=74
If you are interested, please register at the link above - there is no need to reply direct to me, although I am happy to answer any queries on content, timing or registration.
Kind regards
Malcolm Morrissey
Perceptive Informatics
Evaluating and Implementing Complex Randomization Solutions: Randomization in Multi-Armed Trials
Tuesday, September 15, 2009
Thursday, September 17, 2009
Trials of many (greater than two) treatments are common, particularly dose finding trials in Phase IIB where trials of four or more treatments are often seen. Such trials will almost certainly be conducted at multiple centers, given the sponsor's desire to speed up the development program.
When conducting such multicenter trials, the study team will always have to consider whether the randomization of the trial is to be stratified or balanced in some way by the participating center. In addressing this question there are three considerations for the study team: impact on power, medication needs and predictability.
This talk will describe the use of three complex list-based randomization solutions that have been recently developed and implemented; two of the solutions have not been presented or previously published. The techniques maintain various degrees of control over allocations at the site and study as a whole; consequently the methods can help with conserving supplies of medication while maintaining balance at the study level. Simulation evidence will be presented for each technique.
By attending this webinar, you will:
§ Become aware of randomization considerations for study teams
§ Learn how to save trial medication in multi-armed trials
§ Understand the pros and cons for each technique presented
Target Audience:
This webinar is suitable for all members of study teams including study team leaders, drug supply managers and statisticians.
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