Dear fsl experts,
I'm preparing a case report on a patient with a neurodegenerative
disease affecting mainly the white matter.
I want to comare his FA map with 20 controls (healthy and similar
age). I was using the TBSS script to align the FA maps of Patient and
My question is: If I want to compare the FA map of the patient with
the controls should I use the randomise tool with the 20 controls
being one group and the patient being the 2nd group. Is that a valid
analysis to say something about where the patient differs from normal
I also have data for the patient after one year of treatment and a
rescan on 2 of the controls.
I want to ask: Did the treatment reversed some of the differences in
FA map differences?
My original idea was
1) Compare Patient_Before_Treatment with Controls and then Compare
Patient_After_Treatment with Controls.
2) Compare the resulting tstat of Con_vs_BeforeTreatment with
I did the above analysis and have promising and hypothesis conform
results but I have my doubts on the statistical validity.
Can you give me some advice on this? Is randomise the right tool to
compare single subjects agains a control group?