BIOINFORMATICIANS
£29,663- £35,399 per annum inclusive
London W12

The MRC Clinical Science Centre (http://www.csc.mrc.ac.uk) is one of three
Institutes core funded by the Medical Research Council, UK.
Post holders will become part of a growing Computational Biology community
at the CSC.
We have three new openings in Bioinformatics:
* Epigenetics, Development and Cancer Section (3 years)
Reference - CSC09/297
The Epigenetics, Development and Cancer Section of the CSC takes a
multidisciplinary approach to gain fundamental insights into the epigenetic
and transcriptional control of gene expression, development, and cancer. Our
work aims at a better understanding of human health and disease and the
development of new biological therapies
(http://www.csc.mrc.ac.uk/Research/Groups/EDC/).
Working closely with biologists and computational scientists at the CSC,
Imperial College and external collaborators you will provide support and
training to research groups in the Epigenetics, Development and Cancer
Section. You will use existing tools and develop novel approaches for the
analysis and visualisation of data from array hybridisation and high
throughput sequencing (RNA-seq, ChIP-seq) projects. You will integrate these
data with information from genomic databases (sequence features,
conservation, repetitive elements, etc.). The post requires significant
postgraduate experience in bioinformatics, analysis of microarray data,
programming, a good understanding of biology and excellent communication
skills. 
* Physiological Genomics and Medicine Group (3 years) 
Reference - CSC09/296
The post-holder will work on a functional genomics programme to investigate
the molecular mechanisms and pathways underlying common human diseases such
as heart failure, kidney failure and the autoimmune disease systemic lupus
erythematosus. The project, funded by the CSC, is an interdisciplinary
collaboration between clinicians, basic scientists, statisticians and
bioinformaticians working with colleagues throughout the UK and more widely
in Europe and North America. 

The Group, headed by Professor Tim Aitman, has access to state-of-the-art
genomics facilities, including next-generation sequencing (Solexa/Illumina,
SOLiD, Roche 454), ultra high-throughput genotyping and microarray
(Affymetrix, Agilent) platforms. The post-holder will take responsibility
for and co-ordinate data management, analysis and interpretation and will
assist with experimental design for the Group's research activities working
together closely with other geneticists and bioinformaticians at the CSC,
Imperial College London and other collaborating research centres. 

Applicants will have expertise in the integrative analysis of
next-generation sequencing and microarray data.  Programming skills in a
scripting language and a statistical software package are essential.
Experience in working in a distributed computing environment is desirable.
Excellent communication skills are essential.  

* Genomics Laboratory (permanent) Reference - CSC09/298

The CSC Genomics Laboratory (http://www.csc.mrc.ac.uk/ResearchFacilities/)
provides state-of-the-art facilities for high throughput genomics research
for investigators at the CSC, Imperial College using conventional (ABI 3730)
and next generation sequencing (Solexa, ABI SOLiD and Roche 454 platforms)
and microarray (Affymetrix and Agilent) technologies. 

This permanent position is for a Bioinformatician specialised in high
throughput genomics data analysis to facilitate the work of various research
groups in the CSC using next generation sequencing and microarray
technologies. You will perform bioinformatics analysis of different genomics
data modalities and will provide support to research groups working on the
genomic and epigenetic control of gene expression to investigate the genetic
basis of common human diseases.
Applicants should have experience in genome analysis, microarray data
analysis, handling of large-scale genomics data and some programming skills.
Previous experience in analyzing high throughput sequencing data would be an
advantage. 
For all positions, a PhD or equivalent experience in Bioinformatics is
essential. 
Please refer to the Job Descriptions and Person Specifications for a full
breakdown of applicant requirements.

Closing date for applications is 25th June 2009.



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