Hello SPMers,
I am preparing a data processing pipeline for VBM analysis of T1 data
collected from a paediatric population (boys aged 7-12 years old). I created
custom templates using TOM. I point the "tissue probability maps" to the
said templates in either VBM5.1 or the Segment routine but I do not
understand the effect of "affine regularisation" and why the only options
that exist are "ICBM European," "Asian," "average" and "none." Is average
the correct choice? Given my small sample size (10 patients and 10 controls)
and that I was careful to create templates from an appropriate reference
population it does not seems that this is the best choice.
Lastly, does it even matter if I choose to complete my statistical analysis
on the "modulated normalised non-linear only" images generated by VBM5.1?
Cheers,
Deryk
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