The protein wolves get it - and it's never heard from or seen again.

Artem


---
When the Weasel comes to give New Year's greetings to the Chickens no good
intentions are in his mind.

-----Original Message-----
From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jacob
Keller
Sent: Wednesday, February 25, 2009 4:04 PM
To: [log in to unmask]
Subject: Re: [ccp4bb] protein folds

What happens when a single protein strays from the fold?

Jacob


----- Original Message ----- 
From: "Edward A. Berry" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Wednesday, February 25, 2009 2:48 PM
Subject: Re: [ccp4bb] protein folds


> As an outsider to this field, it would seem another way to approach it
> would be to ask, of the currently known folds, how many have only one
> member (excluding evolutionarily related protein families)?
> 
> If a large number of folds have only been sampled once, it is likely
> that there are others that have not been sampled at all. If every known
> fold has at least 5 independently-evolved examples solved, then it is
> less likely that some have been missed.
> 
> If at this stage there are still many folds with only one known example,
> then probably in fact many folds are represented by a single protein
> family, in which case it will be necessary to solve a representative from
> every family to be sure we're not missing a fold.
> 
> 
> Paul Emsley wrote:
>> Jayashankar wrote:
>>> Dear Folks,
>> 
>> Dear gmail-user,
>> 
>>>
>>> The last novel proteins fold were from the yr 2007(pdb statistics),
>>> From 2007 to till date no novel fold has been identified, this mean 
>>> the present 1283 fold are the final or
>>> should I wait, if so , with what criteria do I expect for a new 
>>> fold..or what are the expectations ... [snip]
>> 
>> 
>> Here's an experiment:
>> 
>> Find a blindfold and put it on.  Oh, but before you do that, take a
>> map of England and place it on a dartboard.
>> 
>> Now take 56066 darts and throw them at the map on the board.
>> 
>> Take off the blindfold and investigate where the darts hit.  Did you
>> hit all the towns and cities? You hit London, Birmingham and Leeds
>> almost certainly.  But what about Brighton, did you get that?  How
>> about Clitheroe, was that hit? (Does Clitheroe count anyway or is
>> that just another part of Preston?)
>> 
>> I hope that that provides you some with insight.
>> 
>> Paul.
>> 
>