Along the lines of Jeroen's suggestion, we've enjoyed success with
surface entropy reduction mutations to alter crystal contacts. UCLA
has an SER analysis server at:
http://nihserver.mbi.ucla.edu/SER/
Ho
UC Berkeley
-----------------------------------------------------------------------------------------------------
It mostly means little intermolecular contacts in one direction because=20
of charge repulsion, shape incomplementarity etc etc.
One thing to try is screen for additives that can help to make more=20
contacts between the layers or, screen for new crystal forms using=20
microseed matrix screening!
- J. -
|