hi
yes this may happen in some circumstances....have a look at
J Am Chem Soc. 2008 Oct 15;130(41):13514-5.
> Hi,
>
> I had a question about flexibility in ligand binding in an enzyme active
> site. Is it possible for a substrate/product analogue to bind in more
> than
> one conformation in the active site. Since the ligand/enzyme interactions
> are very specific I am a little confused about this.
> Also which program would you use if you have to refine with alternate
> ligand
> conformation.
> Please mention if you have ever come across any paper that explains such a
> phenomena.
> Thanks a lot.
>
> Mariah
> --
> Mariah Jones
> Department of Biochemistry
> University of Florida
>
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