Applications are invited for the following positions as

 


    *                                                        Ph.D.
    student (female/male)*

and


    *                                                    Postdoctoral
    fellow (female/male)*

 


    *                                                    for Structural
    Biology of Infections *

*(Protein Crystallography / Drug Design / Synthetic Organic Chemistry).*

* *

The positions are available at the Institute of Biochemistry (Director: 
Prof. Dr. Rolf Hilgenfeld), University of Lübeck, Germany. 


*1.   **Ph.D. studentship, reference number 434/08*

*Research area: Investigation of interactions between proteins of 
Chlamydia and host cell factors *

Methodology: Crystallography/Molecular Biology/Microbiology

Duration: initially limited to two years, extension possible

 

*2.  **Two Ph.D. studentships or one postdoctoral fellowship, reference 
number 435/08*


      *Research area: Investigation of interactions between Influenza
      viruses and host cell proteins *

Methodology: Crystallography/Molecular Biology

Duration: initially limited to two years, extension possible

 

*3. Ph.D. studentship, reference number 436/08*


      Research area: Flaviviral enzymes as targets for antiviral therapies

Methodology: Crystallography/Molecular Biology/Drug Design

Duration: initially limited up to two years, extension possible


*4. Two Ph.D. studentships or one postdoctoral fellow, reference number 
437/08*


      Research area: Enterovirus proteases as targets for antiviral
      therapies

Methodology: Synthetic organic chemistry /Crystallography

Duration: initially limited up to two years, extension possible

 

*5.  **Ph.D. studentship, reference number 438/08*


      *Research area: Host cell proteins as targets for anti-HIV therapy*

Methodology: Crystallography/Molecular Biology

Duration: initially limited to two years, extension possible



The Institute of Biochemistry (www.biochem.uni-luebeck.de 
<http://www.biochem.uni-luebeck.de>) possesses a long-standing 
reputation for research on the molecular basis of intracellular 
infections by RNA viruses (particularly coronaviruses including the SARS 
virus), bacteria and protozoa, with the objective to design and develop 
new antiinfective drugs (e.g. /EMBO J./ *21*, 3213 (2002), /Science/ 
*300*, 1763 (2003), /PNAS/ *100*, 13190 (2003), /Cell/ *117*, 57 (2004), 
/JMB/ *354*, 25 (2005), /JBC/ *281*, 25425 (2006), /Chem Biol/ *15*, 597 
(2008), /JMB/ *383*, 1081(2008)).

The announced positions should push forward the research in the field of 
structural biology of infections, particularly the characterization of 
protein-protein interactions between viral or bacterial virulence 
factors and host cell components. A further objective consists in the 
structural characterization of the binding properties of inhibitors to 
target proteins. Based on X-ray structures of the corresponding 
complexes, such lead compounds are designed and synthesized at the 
Institute of Biochemistry. The successful candidates will gain profound 
experience in a broad variety of experimental and computational 
techniques. Various techniques required for the preclinical development 
of antiinfective drugs such as proteomics, crystallization, X-ray 
structure determination as well as chemical synthesis of inhibitors are 
available in-house. The institute is well equipped with crystallization 
facilities such as crystallization robots and imaging systems. We also 
operate an outstation at DESY (Hamburg) with direct access to 
synchrotron radiation.

The positions will be paid according to E13 on the TV-L scale in case 
all contractual prerequisites are fulfilled. A final grading remains 
reserved. The working schedule will be in accordance to § 6 TV-L.

The university seeks to achieve a balance between female and male 
coworkers and advocates the employment of disabled individuals. 
Accordingly, applications of female or disabled candidates with 
equivalent qualification will be preferably considered.

The announcement addresses particularly successful candidates 
(female/male) holding a degree in biochemistry, chemistry, and pharmacy. 
Further information can be obtained from the director of the institute, 
Prof. Dr. Rolf Hilgenfeld ([log in to unmask] 
<mailto:[log in to unmask]>).

 

Applications in written form are expected until January 12, 2009 with 
indication of the corresponding reference number to:  **

*Universität zu Lübeck*

*-Der Präsident-*

*- Dezernat Personal -*

*Ratzeburger Allee 160*

*23538 Lübeck*

-- 

Dr. Holger Steuber
Professor (W1) for Structure-based Drug Design

Institute of Biochemistry
University of Luebeck
Ratzeburger Allee 160
23538 Luebeck
Germany

Phone : +49-451-500-4065
Fax     : +49-451-500-4068
E-mail : [log in to unmask]